Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.
Y. Pikman, N. Ocasio-Martinez, G. Alexe, S. Kitara, F. F. Diehl, A. L. Robichaud, A. Conway, A. Su, J. Qi, G. Roti, C. A. Lewis, A. Puissant, M. G. Vander Heiden, K. Stegmaier
This study identifies SHMT1 and SHMT2 as therapeutic targets in T-ALL by showing their inhibition impairs leukemia progression and is effective despite methotrexate resistance.
bioRxiv · Feb 6, 2020Cancer Biology