J. Qi

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Panax ginseng enhances the effect of metoprolol in chronic heart failure by inhibiting autophagy

This study shows that Panax ginseng combined with metoprolol improves survival and heart function in HF mice by inhibiting autophagy via the PI3K/Akt/mTOR pathway.

The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

This study shows that gut microbiota influence liver tumor growth and behavior through the vagus nerve, with cholinergic signaling and CD8+ T cells playing key roles.

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

Targeting transcription factors through an IMiD independent zinc finger domain

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

Single-cell Sequencing Highlights Heterogeneity and Malignant Progression in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

This study uses single-cell RNA-seq to analyze the progression from actinic keratosis to cutaneous squamous cell carcinoma, identifying key driver genes and tumor microenvironment interactions.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

SALLB not targeted by IMiDs is important for maintenance of liver cancer cells

The paper identifies a compound that degrades both SALL4 isoforms, overcoming IMiD limitations in liver cancer treatment.

Utilizing a dual endogenous reporter system to identify functional regulators of aberrant stem cell and differentiation activity in colorectal cancer

Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks

This paper shows that EP300 deficiency causes chronic replication stress and genomic instability in ATLL cells by impairing fork protection and leading to DNA damage and mitotic defects.

A CRISPR-drug perturbational map for identifying new compounds to combine with commonly used chemotherapeutics.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combine with droplet microfluidics

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

Phylogenomics reveals incomplete lineage sorting and ancient hybrid drove the radiation of macaques

This study uses phylogenomic analysis of macaque genomes to show that incomplete lineage sorting and ancient hybridization contributed to the radiation of macaques.

KDM5A/B promotes HIV-1 latency and KDM5 inhibitors promote HIV-1 lytic reactivation

This study shows that KDM5A/B promote HIV-1 latency and their inhibition with JQKD82, combined with AZD5582, reactivates HIV-1 and induces cell death.

Efficient Multi-Label Attribute Classification and Recognition of Microbiological Bacteria Based on Deep Learning and model fine-tuning

This paper proposes a deep learning model for multi-label bacterial classification, showing it is lighter, faster, more accurate, and efficient than existing methods.

Droplet microfluidics forward for tracing target cells at single-cell transcriptome resolution

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibility

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

Factors that affected the qualification of standardized residency training of internal medicine: a prospective longitudinal study

This study evaluates factors affecting the qualification rates of standardized internal medicine residency training in China, identifying regional origin and training duration as independent predictors.

The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway

This study identifies Beauvericin as an activator of dendritic cells via the TLR4 signaling pathway, suggesting its potential as a vaccine adjuvant or cancer immunotherapy.

Multimodal Single-Cell Characterization of the Human Granulocyte Lineage

This study uses multi-modal CITE-seq to accurately characterize human granulocytes, showing higher transcript detection with BD Rhapsody compared to 10X Genomics.

Locally secreted BiTEs complement CAR T cells by enhancing solid tumor killing

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

The race goes on: A fall armyworm-resistant maize inbred line influences insect oral secretion elicitation activity and nullifies herbivore suppression of plant defense

This study identifies a maize inbred line, Xi502, that mounts effective defense against fall armyworm, showing distinct transcriptomic and elicitation responses compared to the susceptible line B73.

Verticillium dahliae effector VDAL protects MYB6 from degradation by interacting with PUB25/26 E3 ligases for enhancing Verticillium wilt resistance in Arabidopsis

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

Aggregation-induced emission dots assisted non-invasive fluorescence hysterography in near-infrared IIb window

This study uses AIE dots for non-invasive NIR-IIb fluorescence hysterography to visualize uterine structures and function in mice without impairing reproductive capacity.

Potentiating CD8+ T cell antitumor activity by targeting the PCSK9/LDLR axis

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

Structural basis of SARS-CoV-2 polymerase inhibition by Favipiravir

This paper determines the cryo-EM structure of Favipiravir bound to SARS-CoV-2 polymerase, revealing its base-pairing mechanism and implications for antiviral drug development.