A. Su

Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma

This study uses isotope tracing to show that β-catenin mutations in HCC suppress phosphatidylcholine synthesis while increasing fatty acid oxidation.

A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

The paper identifies a 26-gene expression signature in high-risk gastric intestinal metaplasia (GIM) that localizes to intestinal stem-like cells and is associated with increased gastric cancer risk.

Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated SPP1+ macrophages and fibroblasts

This paper identifies SPP1+ macrophages and fibroblasts in liver metastatic CRC TME that form immunosuppressive networks, promoting tumor growth and poor prognosis.

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.

This study identifies SHMT1 and SHMT2 as therapeutic targets in T-ALL by showing their inhibition impairs leukemia progression and is effective despite methotrexate resistance.

Sequence, Structure and Context Preferences of Human RNA Binding Proteins

The paper presents affinity landscapes of 78 human RNA binding proteins using deep sequencing to determine sequence, structure, and context preferences, revealing patterns of low motif diversity and contextual feature preferences.