Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
E. D. O'Sullivan, K. J. Mylonas, R. Bell, C. Carbalho, D. P. Baird, C. Cairns, K. M. Gallagher, R. Campbell, M. Docherty, A. Laird, N. Henderson, T. Chandra, K. Kirschner, B. Conway, G. Dihazi, , D. Ferenbach
This study identifies PDIA3 as a key mediator of fibrosis by analyzing senescent epithelia in murine and human models, showing its inhibition reduces fibrosis.
bioRxiv · Mar 21, 2022Cell Biology