K. Kirschner

Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer associated fibroblasts

This study shows that mitochondrial dsRNA from B-ALL cells triggers MSC to become CAFs, linking genetic subtypes to survival outcomes.

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma

The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

This study identifies PDIA3 as a key mediator of fibrosis by analyzing senescent epithelia in murine and human models, showing its inhibition reduces fibrosis.

Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3

This study identifies differential regulation of lung γδ T cell subsets by PD-1 and TIM-3 using single-cell RNA sequencing and flow cytometry.

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

This study quantifies gene-specific fitness effects of CHIP drivers over 12 years using longitudinal sequencing data and a new DIF filtering method, showing gene-specific differences can inform personalized clinical management.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

Ly6C defines a subset of memory-like CD27+ γδ T cells with inducible cancer-killing function

The paper identifies two subsets of CD27+ γδ T cells in mice, distinguished by Ly6C expression, with one subset showing memory-like properties and cancer-killing potential.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.