T. Chandra

Machine learning recognises senescence in glioblastoma and discovers senescence-inducing compounds

The paper uses machine learning to identify senescent glioblastoma cells and discovers compounds that induce senescence in these cells.

Probabilistic inference of epigenetic age acceleration from cellular dynamics

The paper develops a probabilistic model to infer epigenetic age acceleration from cellular dynamics, identifying acceleration and bias as measurable components linked to physiological traits and genomic loci associated with ageing.

Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

This study identifies PDIA3 as a key mediator of fibrosis by analyzing senescent epithelia in murine and human models, showing its inhibition reduces fibrosis.

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

This study quantifies gene-specific fitness effects of CHIP drivers over 12 years using longitudinal sequencing data and a new DIF filtering method, showing gene-specific differences can inform personalized clinical management.

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease.

The paper uses scRNA-seq to study kidney disease progression and regression, identifying new myeloid cell subtypes and their roles in injury and repair.

Lamina and Heterochromatin Direct Chromosome Organisation in Senescence and Progeria

This study uses polymer physics simulations to show that lamina and heterochromatin interactions drive nuclear organization in senescence and progeria through phase transitions.

Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence

This study shows that inhibiting LSG1, a GTPase involved in 60S ribosome biogenesis, induces cellular senescence through ER disruption and cholesterol biosynthesis upregulation, with potential therapeutic implications.