N. Henderson

Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response

This study shows that oncogenic Ras in zebrafish skin triggers phenotypic plasticity in specific keratinocytes and promotes tumour-promoting neutrophils within 24 hours.

The expression of PKM1 and PKM2 in developing, benign, and cancerous prostatic tissues

This study examines PKM1 and PKM2 expression in mouse and human prostatic tissues across development, benign, and cancerous states, revealing distinct patterns in PCa and NEPCa.

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

This study identifies PDIA3 as a key mediator of fibrosis by analyzing senescent epithelia in murine and human models, showing its inhibition reduces fibrosis.

Exploratory polarization facilitates mating partner selection in Saccharomyces cerevisiae

The paper shows yeast cells use mobile polarity sites to explore pheromone gradients, stabilizing only when they detect high pheromone levels, facilitating mating partner selection.

SOX9 is required for kidney fibrosis and regulates NAV3 to control renal myofibroblast function in mice and humans

This study identifies SOX9 as essential for kidney fibrosis and shows it regulates NAV3 to control myofibroblast function in mice and humans.

A macrophage-pericyte axis directs tissue restoration via Amphiregulin-induced TGFβ activation

This study identifies a macrophage-pericyte axis that promotes tissue restoration through Amphiregulin-induced TGFβ activation during acute injury.