Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling
C. Jacques, L. Perrin, J. Ackermann, S. Bell, O. Zajac, A. Lapierre, L. Anger, C. Hallopeau, C. Perez-Gonzalez, L. Balasubramaniam, X. Trepat, B. Ladoux, A. Maitra, R. Voituriez, D. Matic Vignjevic
This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.
bioRxiv · Nov 22, 2023Cell Biology