Author

L. Perrin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

B. Bayarmagnai· 2 shared B. Gligorijevic· 2 shared A. Darbois· 1 shared A. Lapierre· 1 shared A. Maitra· 1 shared A. Sutra Del Galy· 1 shared B. Ladoux· 1 shared C. Cao· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

B. Bayarmagnai

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single-molecule evidence of Entropic Pulling by Hsp70 chaperones

V. Rukes, M. E. Rebeaud, L. Perrin, P. De Los Rios, C. Cao

This study uses single-molecule nanopore experiments to demonstrate Hsp70 chaperones exert forces equivalent to 46 pN to extract trapped polypeptides, supporting the Entropic Pulling mechanism.

bioRxiv · Feb 6, 2024Biophysics

Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling

C. Jacques, L. Perrin, J. Ackermann, S. Bell, O. Zajac, A. Lapierre, L. Anger, C. Hallopeau, C. Perez-Gonzalez, L. Balasubramaniam, X. Trepat, B. Ladoux, A. Maitra, R. Voituriez, D. Matic Vignjevic

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

bioRxiv · Nov 22, 2023Cell Biology

In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4+ Th1 cell response

A. Sutra Del Galy, S. Menegatti, J. Fuentealba, F. Lucibello, J. Helft, A. Darbois, M. Saitakis, J. Tosello, D. Rookhuizen, L. Perrin, M. Deloger, P. Gestraud, G. Socie, S. Amigorena, O. Lantz, L. Menger

The paper identifies SOCS1 as a key intrinsic checkpoint limiting CD4+ Th1 cell response through in vivo CRISPR screens and shows targeting SOCS1 enhances antitumor T-cell therapy.

bioRxiv · Apr 12, 2021Immunology

Invadopodia enable cooperative invasion and metastasis of breast cancer cells

L. Perrin, E. Belova, B. Bayarmagnai, E. Tuzel, B. Gligorijevic

This study shows that invadopodia in leader cells enable cooperative invasion and metastasis of breast cancer cell clusters.

bioRxiv · Feb 13, 2021Cancer Biology

Invadopodia degrade ECM in the G1 phase of the cell cycle

B. Bayarmagnai, L. Perrin, K. Esmaeili Pourfarhangi, B. Gligorijevic

This study shows breast carcinoma cells degrade ECM preferentially during G1 phase via invadopodia, with p27kip1 regulating invadopodia turnover and ECM degradation.

bioRxiv · Sep 27, 2018Cancer Biology