Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions
S. Bobone, L. Pannone, B. Biondi, M. Solman, E. Flex, V. Canale, P. Calligari, C. De Faveri, T. Gandini, A. Quercioli, G. Torini, M. Venditti, A. Lauri, G. Fasano, J. Hoeksma, , L. Stella
This study develops peptide-based SHP2 inhibitors that target protein-protein interactions, showing higher affinity for pathogenic variants and efficacy in zebrafish embryos.
bioRxiv · Aug 28, 2020Biophysics