A. Letian

Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation

This study shows that ketogenesis in innate immune cells is not essential for metabolism or age-related inflammation, but liver-derived ketone bodies are critical for controlling inflammation and metabolism during aging.

Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells.

The paper uses proximity proteome mapping to show that anti-PD-L1 therapy disrupts specific PD-L1-dependent pathways in EGFR-mutant lung cancer cells, leading to altered cell migration and EGFR stability.