Loss of Caspase-8 function in combination with SMAC mimetic treatment sensitizes Head and Neck Squamous Carcinoma to radiation through induction of necroptosis
B. Uzunparmak, M. Gao, A. Lindemann, K. Erikson, L. Wang, E. Lin, S. Frank, F. O. Gleber-Netto, M. Zhao, H. D. Skinner, J. Newton, A. G. Sikora, J. N. Myers, C. R. Pickering
This study shows that loss of CASP8 function combined with SMAC mimetic treatment increases necroptosis in HNSCC, enhancing radiation sensitivity.
JCI Insight · Dec 3, 2020Peer-reviewedCancer Biology