S. Frank

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

This study shows that acute CDK12 loss in prostate cancer causes HR deficiency via polyadenylation, but chronic loss leads to adaptation, making PARP inhibitors ineffective and suggesting CDK13 targeting as a new therapeutic approach.

Bacterial microcompartment utilisation in the human commensal Escherichia coli Nissle 1917

This study demonstrates ethanolamine utilization and eut BMC formation in E. coli Nissle 1917 through growth assays, microscopy, and flux balance analysis, showing comparable metabolism to Salmonella enterica with distinct ammonium release.

The balance between growth and resistance is shifted to the latter by overaccumulation of chloroplast-nucleus located WHIRLY1 in barley

Overaccumulation of WHIRLY1 in barley shifts the balance from growth to stress resistance by enhancing defense gene expression and reducing photosynthesis and growth.

Loss of Caspase-8 function in combination with SMAC mimetic treatment sensitizes Head and Neck Squamous Carcinoma to radiation through induction of necroptosis

This study shows that loss of CASP8 function combined with SMAC mimetic treatment increases necroptosis in HNSCC, enhancing radiation sensitivity.

A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.

Split-HaloTag Imaging Assay for Sophisticated Microscopy of Protein-Protein Interactions in planta

The paper introduces a Split-HaloTag imaging assay for studying protein-protein interactions in plants using advanced microscopy techniques.

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

The paper identifies a CHD6 mutation causing Hallermann-Streiff syndrome and shows it disrupts autophagy and DNA damage response through chromatin remodeling.

Notch3 promotes prostate cancer-induced bone lesion development via MMP3

This study shows Notch3 promotes osteoblastic bone lesions in prostate cancer by inhibiting osteoclasts and enhancing osteoblasts through MMP-3.

PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging

This study shows that PGC-1α improves mitochondrial function and reduces sarcoplasmic reticulum stress and cell death in aging skeletal muscle, thereby delaying aging effects.