M. Gao

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from individuals exposed only to ancestral SARS-CoV-2.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Spherical Echo-Planar Time-resolved Imaging (sEPTI) for rapid 3D quantitative T2* and Susceptibility imaging

This paper introduces sEPTI, a 3D imaging technique for rapid whole-brain T2* and susceptibility mapping, achieving faster imaging and improved quality compared to existing methods.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

Pharmacological characterization of seven human histamine H3 receptor isoforms

This study pharmacologically characterizes seven human H3R isoforms, finding differences in agonist and inverse agonist binding affinities, with implications for drug discovery.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

IL-2-induced Stat3 Signaling is Critical for Effector Treg Cell Programming

This study identifies IL-2-induced Stat3 signaling as essential for programming iTreg cells to differentiate into eTreg cells and achieve IL-10 transcriptional competency.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Synergistic activity of rhamnolipid combined with linezolid against linezolid-resistant Enterococcus faecium

This study shows that rhamnolipids combined with linezolid synergistically enhance antibacterial activity against linezolid-resistant Enterococcus faecium through multiple assays and mouse models.

Rapid mode switching facilitates the growth of Trichodesmium: A model analysis.

This study develops a metabolic model of Trichodesmium showing that rapid switching between photosynthetic and non-photosynthetic states enhances growth by improving metabolic efficiency.

A novel subset of colonocytes targeted by Citrobacter rodentium elicits epithelial MHCII-restricted help from CD4 T cells

The paper identifies a novel subset of colonocytes targeted by Citrobacter rodentium that require MHCII-restricted help from CD4 T cells for IL-22 signaling and immune protection.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

A novel purity analysis method of bovine milk-derived exosomes by two-dimensional high-performance liquid chromatography

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets

A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector

This study identifies how the tomato yellow leaf curl virus uses a host-mimicking protein domain to disrupt plant processes and attract insect vectors, facilitating viral spread.

From whole genome to probiotic candidates: a study of potential Lactobacillus strain selection for vaginitis treatment

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

Genome-wide libraries for protozoan pathogens drug target screening using yeast surface display

The paper develops a method to construct genome-wide libraries for yeast surface display and identifies drug targets in protozoan pathogens using a fitness screen.

Acetylation of a fungal effector that translocates host PR1 facilitates virulence

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.

Direct N-Me Aziridination Reaction Enables Pinpointing C=C Bonds in Lipids with Mass Spectrometry

This paper introduces a chemical derivatization method using N-Me aziridination to precisely identify C=C bond positions in lipids via mass spectrometry.

Dual-Resolving of Lipid Positional and Geometric Isomers of C=C Bonds via Bifunctional Photocycloaddition-Photoisomerization Reaction System and Mass Spectrometry

This paper develops a bifunctional reaction system to simultaneously resolve lipid positional and geometric isomers using mass spectrometry, revealing structural patterns in bacteria and tracking changes in mouse brain ischemia.

Globally invariant metabolism but density-diversity mismatch in springtails

The paper estimates global springtail biomass and density, finding similar energy use across latitudes but mismatch between diversity and density.

Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

Parapatric speciation with recurrent gene flow of two sexual dichromatic pheasants

This study shows that two pheasant species have experienced recurrent gene flow during speciation, with evidence of long-term gene flow after initial divergence and ongoing contact in recent times.

Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes

A CRISPR-Cas assisted shotgun mutagenesis method for evolutionary genome engineering

This paper introduces CARM, a CRISPR-Cas-based method for whole-genome mutagenesis, and demonstrates its application in evolving yeast strains for increased beta-carotene and S-adenosyl-L-methionine production.