E. Lin

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules

This study develops an inducible mismatch repair system to identify targets of orphan cytotoxins by screening for compound resistance mutations in engineered cell lines.

Mechanical resistance of the environment affects root hair growth and nucleus dynamics

This study shows that mechanical resistance affects root hair growth speed and nucleus movement, with stiffer environments producing shorter root hairs and altered nucleus positioning.

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

Single-Molecule Dynamics of SARS-CoV-2 5' Cap Recognition by Human eIF4F

This study investigates how eIF4F subunits coordinate to recognize the SARS-CoV-2 5' cap using single-molecule fluorescence, showing that eIF4A enhances cap accessibility and full complex formation affects eIF4E-cap interaction.

Feeding Experimentation Device version 3 (FED3): An open-source home-cage compatible device for measuring food intake and operant behavior

The paper introduces FED3, an open-source device for measuring food intake and operant behavior in rodents, demonstrating its utility in quantifying intake, meal patterns, and operant learning across multiple institutions.

Loss of Caspase-8 function in combination with SMAC mimetic treatment sensitizes Head and Neck Squamous Carcinoma to radiation through induction of necroptosis

This study shows that loss of CASP8 function combined with SMAC mimetic treatment increases necroptosis in HNSCC, enhancing radiation sensitivity.

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an AAV hACE2 Mouse Model and non-human primates

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection

This study identifies γδ T cells as critical early mediators of a wound healing response during cutaneous poxvirus infection, independent of their role in virus replication control.

Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical Mapping

This study develops a drug screening platform using human iPSC-derived atrial cardiomyocytes and optical mapping to evaluate atrial-selective compounds.

Protective immunity against severe malaria is associated with antibodies to a conserved repertoire of PfEMP1 variants

The paper identifies antibody responses to conserved PfEMP1 variants associated with protection against severe malaria, while showing limited association with uncomplicated malaria.