ImmunologybioRxiv
Collagen density regulates the activity of tumor-infiltrating T cells
D. E. Kuczek, A. M. Hvid Larsen, M. Carretta…·D. H. Madsen
This study shows that high collagen density in tumors reduces T cell proliferation and cytotoxicity, while increasing regulatory T cells, suggesting collagen density modulates T cell function in the tumor microenvironment.
DOI 10.1186/s40425-019-0556-6