Neoantigen Cancer Vaccines and Different Immune Checkpoint Therapies Each Utilize Both Converging and Distinct Mechanisms that in Combination Enable Synergistic Therapeutic Efficacy
S. Keshari, A. S. Shavkunov, Q. Miao, A. Saha, C. D. Williams, A. M. Highsmith, J. E. Pineda, E. Alspach, K. Hu, K. E. Pauken, K. Chen, M. M. Gubin
This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.
bioRxiv · Dec 20, 2023Immunology