K. Hu

The initiation and early development of apical-basal polarity in Toxoplasma gondii

This study investigates the initiation and early development of apical-basal polarity in Toxoplasma gondii using expansion microscopy, revealing the synchronized development of apical and basal structures and the synergistic role of APR2 and KinesinA.

Assessing drug uptake and response differences in 2D and 3D cellular environments using stimulated Raman scattering microscopy

This study compares drug uptake and response in 2D and 3D cell cultures using SRS microscopy, finding that 3D spheroids show greater drug tolerance despite similar intracellular drug levels.

Neoantigen Cancer Vaccines and Different Immune Checkpoint Therapies Each Utilize Both Converging and Distinct Mechanisms that in Combination Enable Synergistic Therapeutic Efficacy

This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.

RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4

This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.

The initiation and early development of the tubulin-containing cytoskeleton in the human parasite Toxoplasma gondii

This study examines the development of tubulin-containing structures in Toxoplasma gondii using advanced imaging techniques, revealing distinct developmental patterns and symmetry changes.

CSTA: A Biomarker Regulating Esophageal Stricture Epithelial Barrier, Potential Medication Target

The paper identifies CSTA as a biomarker for esophageal epithelial barrier function and shows FK506 can rescue CSTA-knockdown effects in strictures.

Inhibiting the GPI Transamidase Subunit GPAA1 Abolishes CD24 Surface Localization and Enhances Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

This study identifies GPAA1 as a regulator of CD24 surface expression and shows that inhibiting GPAA1 enhances macrophage-mediated phagocytosis of ovarian cancer cells.

The cortical microtubules of Toxoplasma gondii underlie the helicity of parasite movement

This study investigates the role of cortical microtubules in Toxoplasma gondii motility, showing that their destabilization reduces helical movement without affecting speed or invasion/egress.

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Evolution of m6A related genes in insects and function of METTL3 in embryonic development of silkworm.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

A novel batokine Breg controls adipose thermogenesis and glucose homeostasis

This study identifies Breg as a batokine that regulates adipose thermogenesis and glucose homeostasis, showing its role in energy metabolism and potential therapeutic applications.

An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii

This study identifies Pcr2 as a critical protein for movement and invasion in Toxoplasma gondii, showing that its absence impairs egress and tissue destruction.

Expression and functional evaluation of recombinant human ABO blood group antigen cleaving glycoside hydrolases α-N-acetylgalactosaminidase, α-galactosidase, and endo-β-galactosidase produced in Escherichia coli

This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.

An in situ quantitative map of initial human colorectal HIV transmission

This study quantifies HIV transmission dynamics in human colorectal tissue, showing HIV localizes to mucosal dendritic cells and submucosal macrophages rather than CD4+ T-cells.

Super-Resolution Electrochemical Impedance Imaging with a 100 x 100 CMOS Sensor Array

The paper introduces a 100 x 100 CMOS sensor array for super-resolution electrochemical impedance imaging, demonstrating sub-cellular permittivity mapping in algae cells.

Extremely bright, near-IR emitting spontaneously blinking fluorophores enable ratiometric multicolor nanoscopy in live cells

The paper introduces a new near-IR fluorophore that enables two-color live-cell SMLM without chemical additives or multiple lasers.

CMOS electrochemical imaging arrays for thedetection and classification of microorganisms

This paper introduces CMOS electrochemical imaging arrays for detecting and classifying microorganisms in their natural environments.

Electrochemical measurements reveal reactive oxygen species in stress granules.

The paper uses electrochemical measurements to show that reactive oxygen species, particularly H2O2, are present in stress granules and may play a role in cellular stress communication and regulation.

Heterologous vaccination regimens with self-amplifying RNA and Adenoviral COVID vaccines induce robust immune responses in mice

This study shows that heterologous vaccination with self-amplifying RNA and adenoviral SARS-CoV-2 vaccines in mice produces stronger antibody and cellular immune responses than single-dose regimens.

BnaA03.WRKY28, interacting with BnaA09.VQ12, acts as a brake factor of activated BnWRKY33-mediated resistance outburst against Sclerotinia sclerotiorum in Brassica napus

Under constant infection by Sclerotinia sclerotiorum, BnaA03.WRKY28 interacts with BnaA09.VQ12 and takes precedence over phosphorylated BnWRKY33 to bind to the BnWRKY33 promoter, thereby weakening resistance but promoting branching.

Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines

The paper evaluates telomerase activation and telomere maintenance in cancer cell lines using genomic and CRISPR data, finding correlations between TERT expression, telomere content, and epigenetic regulation.

Recombinant SARS-CoV-2 RBD molecule with a T helper epitope as a built in adjuvant induces strong neutralization antibody response

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N-nitrosourea-producing enzyme SznF

This paper investigates the assembly of the diiron cofactor in the SznF enzyme, revealing structural changes and an unexpected glutamate ligand that aids in function assignment.

Local Gazetteers Reveal Contrasting Patterns of Historical Distribution Changes between Apex Predators and Mesopredators in Eastern China

This paper uses historical records from local gazetteers to analyze changes in predator distributions in eastern China, finding patterns consistent with mesopredator release and human influence.

Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes

This paper introduces hydrazine-based chemoproteomic probes to target cofactor-dependent enzymes, enabling enzyme discovery and drug development through diverse functional profiling.

A new method for distinguishing human and mouse cells in situ

This paper introduces a method using DAPI staining to distinguish human and mouse cells in situ, showing distinct nuclear structures in mouse cells.

Sample preparation and imaging conditions affect mEos3.2 photophysics in fission yeast cells

This study investigates how formaldehyde fixation and imaging conditions affect the photophysics of mEos3.2 in fission yeast cells, providing a guide for quantitative imaging and counting of mEos3.2-tagged molecules.

Spatial Regulation of MCAK Promotes Cell Polarization and Focal Adhesion Turnover to Drive Robust Cell Migration

This study shows that MCAK's spatial distribution regulates cell migration by affecting MT dynamics, cell polarization, and focal adhesion turnover in RPE-1 cells.

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients