A. Saha

Structure-function relationship of PE11 esterase of Mycobacterium tuberculosis with respect to its role in virulence

This study characterizes the structure and function of PE11 esterase from Mycobacterium tuberculosis, showing its role in virulence and potential as a therapeutic target.

Viral methyltransferase inhibitors: berbamine, venetoclax, and ponatinib as efficacious antivirals against Chikungunya virus

This paper identifies three FDA-approved drugs as inhibitors of Chikungunya virus nsP1 methyltransferase, showing antiviral efficacy in cell-based assays.

Viscoelastic high-molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamics

This study shows that high-molecular-weight hyaluronic acid hydrogels promote faster glioblastoma cell invasion with leader-follower dynamics compared to low-molecular-weight HA hydrogels.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

IL6 mediated cFLIP downregulation increases the migratory and invasive potential of triple negative breast cancer cells

The paper shows that IL6-mediated cFLIP downregulation enhances metastasis in triple negative breast cancer by reducing autophagy.

Neoantigen Cancer Vaccines and Different Immune Checkpoint Therapies Each Utilize Both Converging and Distinct Mechanisms that in Combination Enable Synergistic Therapeutic Efficacy

This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.

Differential Carbonic Anhydrase Activities Control EBV-Induced B-Cell Transformation and Lytic Cycle Reactivation

This study shows that differential carbonic anhydrase activities regulate EBV-induced B-cell transformation and lytic cycle reactivation through transcriptional control by EBNA2 and BZLF1.

PD-L1 activity is associated with partial EMT and metabolic reprogramming in carcinomas

The paper identifies a link between PD-L1 activity, partial EMT, and metabolic reprogramming in carcinomas using transcriptomic data and single-cell RNA-seq.

An Alpha-helical Lid Guides the Target DNA toward Catalysis in CRISPR-Cas12a

This study reveals how the alpha-helical lid in CRISPR-Cas12a guides the DNA target strand toward the RuvC catalytic core through molecular dynamics simulations and experiments.

Quantifying the patterns of metabolic plasticity and heterogeneity along the epithelial-hybrid-mesenchymal spectrum in cancer

The paper analyzes metabolic pathway associations with EMT status across cancer datasets, revealing both general trends and heterogeneity in metabolic plasticity.

Structural basis for Cas9 off-target activity

This study identifies structural mechanisms enabling Cas9 off-target activity through non-canonical base pairing and conformational changes.

Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes

This study shows that cell sex and sex hormones influence glucose and glutamine metabolism in kidney cells, with male cells showing increased metabolic stress and female cells showing better redox balance.

Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence

This study compares RT-qPCR signal intensity and persistence of heat-inactivated and infectious SARS-CoV-2 on different surfaces, showing similar decay patterns and enabling simplified environmental monitoring protocols.

Genome-wide identification, expression and bioinformatic analyses of GRAS transcription factor genes in rice

The paper identifies and analyzes GRAS transcription factor genes in rice, showing their expression under stress conditions and their potential for improving stress tolerance in crops.

Robust RNA editing via recruitment of endogenous ADARs using circular guide RNAs

This paper introduces cadRNAs, circular guide RNAs that recruit endogenous ADARs for efficient and specific RNA editing in vitro and in vivo.

Ribosomal Protein Large subunit RPL6 modulates salt tolerance in rice

This study shows that overexpressing RPL6 in rice improves salt tolerance by enhancing physiological responses and increasing seed yield under salt stress.

Gain of function mutagenesis through activation tagging identifies XPB2 and SEN1 helicase genes as potential targets for drought stress tolerance in rice

Pre-existing resistant proviruses can compromise maintenance of remission by VRC01 in chronic HIV-1 infection

The paper develops a mathematical model to explain VRC01 failure in HIV-1 patients by simulating pre-existing resistant proviruses reactivating during therapy.

Evaluation of modulators of cAMP-response in terms of their impact on cell cycle and mitochondrial activity of Leishmania donovani

This study evaluates cAMP modulators' effects on Leishmania donovani proliferation, cell cycle, and mitochondrial activity, identifying etazolate as a potent anti-leishmanial agent.

Proteasomal Inhibition Triggers Viral Oncoprotein Degradation via Autophagy-Lysosomal Pathway

This study shows proteasomal inhibition causes degradation of EBNA3A and EBNA3C viral oncoproteins via autophagy-lysosomal pathway, while EBNA3B remains stable, suggesting potential therapeutic use of proteasome inhibitors for EBV-related B-cell lymphomas.

Homogenous subgroups of atypical meningiomas defined using oncogenic signatures: basis for a new grading system?

The paper identifies two subgroups of atypical meningiomas using oncogenic signatures, reclassifying 72% of cases as either benign grade 1-like or malignant grade 3-like based on recurrence rates and biological processes.