The ΔF508 CFTR defect: molecular mechanism of suppressor mutation V510D and the contribution of transmembrane helix unraveling
K. S. Simon, K. Nagarajan, I. Mechin, C. Duffy, P. Manavalan, S. Altmann, A. Majewski, J. Foley, J. S. Kaczmarek, S. Bercury, M. Maderia, B. J. Hilbert, J. D. Batchelor, R. Ziegler, J. Bajko, , G. D. Hurlbut
This study investigates the molecular mechanism of the ΔF508 CFTR mutation and how suppressor mutations like V510D and R1070W rescue its function by preventing transmembrane helix unraveling.
bioRxiv · Apr 19, 2020 · PreprintBiochemistry