Author

C. Duffy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

A. Ashworth· 1 shared A. Biancofiori· 1 shared A. Geroge· 1 shared A. Jackson· 1 shared A. Majewski· 1 shared A. Marson· 1 shared A. Nair· 1 shared A. Nikolai-Yogerst· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. Ashworth

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Characterization of Three Variants of SARS-CoV-2 in vivo Shows Host-Dependent Pathogenicity in Hamsters

G. Toomer, W. Burns, M. Melendez, L. Garcia, G. Henry, A. Biancofiori, A. Geroge, C. Duffy, J. Chu, M. Sides, M. Munoz, K. Garcia, A. Nikolai-Yogerst, X. Peng, L. Westfall, R. O. Baker

This study compares the pathogenicity of three SARS-CoV-2 variants in different animal models, showing host-dependent outcomes and the importance of model selection.

bioRxiv · Oct 24, 2022 · PreprintMicrobiology

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

J. Belk, W. Yao, N. Ly, K. Freitas, Y.-T. Chen, Q. Shi, A. Valencia, E. Shifrut, N. Kale, K. Yost, C. Duffy, M. Hwee, Z. Miao, A. Ashworth, C. Mackall, , A. Satpathy

This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.

bioRxiv · Apr 20, 2022Immunology

An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

D. Autheman, C. Crosnier, S. Clare, D. Goulding, C. Brandt, K. Harcourt, C. Tolley, F. Galaway, M. Khushu, H. Ong, A. Romero Ramirez, C. Duffy, A. Jackson, G. J. Wright

This study identifies an invariant Trypanosoma vivax antigen that induces protective immunity through vaccination and monoclonal antibodies.

Nature · May 26, 2021Peer-reviewedMicrobiology

Subjugating Translational Inhibition in Response to Ribosomal Protein Insufficiency by a Herpesvirus Ribosome-Associated Protein

E. I. Vink, J. Andrews, C. Duffy, I. Mohr

This study identifies VP22 as a herpesvirus protein that compensates for ribosomal protein insufficiency to support viral protein synthesis during infection.

bioRxiv · Oct 11, 2020 · PreprintMicrobiology

The ΔF508 CFTR defect: molecular mechanism of suppressor mutation V510D and the contribution of transmembrane helix unraveling

K. S. Simon, K. Nagarajan, I. Mechin, C. Duffy, P. Manavalan, S. Altmann, A. Majewski, J. Foley, J. S. Kaczmarek, S. Bercury, M. Maderia, B. J. Hilbert, J. D. Batchelor, R. Ziegler, J. Bajko, , G. D. Hurlbut

This study investigates the molecular mechanism of the ΔF508 CFTR mutation and how suppressor mutations like V510D and R1070W rescue its function by preventing transmembrane helix unraveling.

bioRxiv · Apr 19, 2020 · PreprintBiochemistry

Variant antigen diversity in Trypanosoma vivax is not driven by recombination

S. Silva Pereira, K. J. G. de Almeida Castilho Neto, C. Duffy, P. Richards, H. Noyes, M. Ogugo, M. R. Andre, Z. Bengaly, S. Kemp, M. M. G. Teixeira, R. Z. Machado, A. P. Jackson

This study shows that recombination does not drive antigenic diversity in Trypanosoma vivax, contrasting with mechanisms in Trypanosoma brucei.

bioRxiv · Aug 20, 2019Microbiology