K. Nagarajan

Genomic regions insertion and deletion in Monkeypox virus causing multi-country outbreak-2022

This study identifies genomic insertions and deletions in Monkeypox virus strains from the 2022 outbreak, linking them to increased transmissibility and genetic divergence from earlier strains.

Molecular Dynamics simulation of TDP-43 RRM in the presence and absence of RNA

This study uses molecular dynamics simulations to analyze TDP-43 RRM domains in the absence of RNA and compares them to RNA-bound structures to identify potential druggable sites.

Genetic diversity and characterization of circular replication(Rep)-encoding single-stranded (CRESS) DNA viruses

This paper characterizes the genetic diversity of Rep and Cap proteins in CRESS-DNA viruses using phylogenetic and CLANS analysis, revealing domain organization and selection pressure in their evolution.

SARS-CoV-2 originated from SARS-CoV-1-related Bat-CoVs through Pan-CoVs rather than from SARS-CoV-2-related Bat-CoVs

This study traces the origin of SARS-CoV-2 to SARS-CoV-1-related bat coronaviruses via pangolin coronaviruses, showing evolutionary intermediates and recombination events.

Pathotyping of Newcastle disease virus: A novel single BsaHI digestion method of detection and differentiation of avirulent strains (lentogenic and mesogenic vaccine strains) from virulent virus

The paper introduces a single BsaHI digestion method to detect and differentiate avirulent NDV strains from virulent ones using RT-PCR and sequence analysis.

The ΔF508 CFTR defect: molecular mechanism of suppressor mutation V510D and the contribution of transmembrane helix unraveling

This study investigates the molecular mechanism of the ΔF508 CFTR mutation and how suppressor mutations like V510D and R1070W rescue its function by preventing transmembrane helix unraveling.