A. Nair

MRPL47 as a Novel Mitochondrial Biomarker for Early Detection and Therapeutic Response in Ovarian Cancer

This study identifies MRPL47 as a biomarker for ovarian cancer, showing its association with poor survival, metabolic changes, and therapeutic response.

Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils

The paper shows that neurons have constitutive endolysosomal perforations enabling internalized alpha-synuclein fibrils to induce aggregation, and inhibiting PIKfyve kinase reduces this effect.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

Multiplexed fluorescence and scatter detection with single cell resolution using on-chip fiber optics for droplet microfluidic applications

The paper introduces OptiDrop, a platform that enables multi-parametric optical sensing of microfluidic droplets with single-cell resolution using on-chip fiber optics.

Myeloid Zfhx3 Deficiency Protects Against Hypercapnia-induced Suppression of Host Defense Against Influenza A Virus

The paper shows that Zfhx3 deficiency in myeloid cells protects mice from hypercapnia-induced immune suppression and worsens influenza A virus infection.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Molecular Dynamics simulation of TDP-43 RRM in the presence and absence of RNA

This study uses molecular dynamics simulations to analyze TDP-43 RRM domains in the absence of RNA and compares them to RNA-bound structures to identify potential druggable sites.

Geminiviral βC1 orchestrates organellar genomic instability to augment viral infection by hijacking host RecA

This study shows that the geminiviral protein βC1 disrupts chloroplast genome stability by hijacking host RecA1 and inducing nuclease activity, thereby enhancing viral infection.

Spatio-temporal analysis identifies hotspots of marine mammal strandings along the Indian coastline: implications for developing a National Marine Mammal Stranding Response and Management policy

This study identifies marine mammal stranding hotspots along the Indian coastline using spatio-temporal analysis and recommends targeted monitoring and response strategies.

Stability of Begomoviral pathogenicity determinant βC1 is modulated by mutually antagonistic SUMOylation and SIM interactions

This study identifies SUMOylation and SIM interactions in βC1 protein as mechanisms modulating its stability and pathogenicity in geminiviral infections.

The ΔF508 CFTR defect: molecular mechanism of suppressor mutation V510D and the contribution of transmembrane helix unraveling

This study investigates the molecular mechanism of the ΔF508 CFTR mutation and how suppressor mutations like V510D and R1070W rescue its function by preventing transmembrane helix unraveling.

Nutritional stress alone can control in vitro tumor formation and its invasive nature

This study shows that nutritional stress affects tumor spheroid formation and invasive behavior, converting non-invasive spheroids into quasi-invasive ones under extreme stress.

Hypercapnia Suppresses Macrophage Antiviral Activity and Increases Mortality of Influenza A 1 Infection via Akt1

This study shows hypercapnia suppresses macrophage antiviral activity and increases influenza A mortality via Akt1 activation in mice.

Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.

This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.

Host dietary specialization and neutral assembly shape gut bacterial communities of wild dragonflies

This study shows that gut bacterial communities in wild dragonflies are mainly shaped by passive processes rather than host-imposed selection, with 76% of bacterial members showing neutral assembly.

Dynein catch bond as a mediator of codependent bidirectional cellular transport

The paper resolves the paradox of codependent bidirectional transport by showing dynein's catchbonding behavior enables regulatory mechanisms in motor function.

Transcriptomes of major renal collecting-duct cell types in mouse identified by single-cell RNA-Seq

The paper identifies transcriptomes of major renal collecting-duct cell types in mice using single-cell RNA-Seq and creates an online gene-expression database.