Author

S. Altmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Imberty· 2 shared A. Landi· 2 shared A. Trefzer· 2 shared B. Diedrich· 2 shared J. Dengjel· 2 shared R. Thuenauer· 2 shared S. Wehrum· 2 shared A. Majewski· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. Imberty

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A gut meta-interactome map reveals modulation of human immunity by microbiome effectors

V. Young, B. Dohai, T. C. Hitch, P. Hyden, B. Weller, N. S. Heusden, D. Saha, J. F. Macgregor, S. B. Maseko, C.-W. Lin, M. Boujeant, S. A. Choteau, F. Ober, P. Schwehn, S. Rothballer, , P. Falter-Braun

The paper identifies a gut microbiome meta-interactome map showing how bacterial effectors modulate human immunity and are enriched in Crohn's disease.

bioRxiv · Sep 25, 2023 · PreprintMicrobiology

The lectin LecB induces patches with basolateral characteristics at the apical membrane to promote Pseudomonas aeruginosa host cell invasion

R. Thuenauer, K. Kühn, Y. Guo, F. Kotsis, M. Xu, A. Trefzer, S. Altmann, S. Wehrum, N. Heshmatpour, B. Faust, A. Landi, B. Diedrich, J. Dengjel, W. Kuehn, A. Imberty, W. Römer

This paper identifies LecB as a Pseudomonas aeruginosa lectin that triggers PI3K signaling and caveolin-1 recruitment at the apical membrane to promote host cell invasion.

bioRxiv · Mar 23, 2022Microbiology

The ΔF508 CFTR defect: molecular mechanism of suppressor mutation V510D and the contribution of transmembrane helix unraveling

K. S. Simon, K. Nagarajan, I. Mechin, C. Duffy, P. Manavalan, S. Altmann, A. Majewski, J. Foley, J. S. Kaczmarek, S. Bercury, M. Maderia, B. J. Hilbert, J. D. Batchelor, R. Ziegler, J. Bajko, , G. D. Hurlbut

This study investigates the molecular mechanism of the ΔF508 CFTR mutation and how suppressor mutations like V510D and R1070W rescue its function by preventing transmembrane helix unraveling.

bioRxiv · Apr 19, 2020 · PreprintBiochemistry

The Pseudomonas aeruginosa lectin LecB causes integrin internalization to facilitate crawling of bacteria underneath host cells

R. Thuenauer, A. Landi, A. Trefzer, S. Altmann, S. Wehrum, T. Eierhoff, B. Diedrich, J. Dengjel, A. Nystroem, A. Imberty, W. Roemer

This paper shows that Pseudomonas aeruginosa's LecB lectin binds integrins and causes their internalization, enabling bacterial crawling under host cells.

bioRxiv · Dec 12, 2019 · PreprintMicrobiology