Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry
Z. Dvorak, F. Felix Kopp, C. M. Costello, J. S. Kemp, H. Li, A. Vrzalova, M. Stepankova, I. Iveta Bartonkov, K. Poulikova, B. Vyhlidalova, L. U. Nordstroem, C. Karunaratne, H. Ranhotra, K. S. Mun, A. P. Naren, , R. B. Sartor
This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.
bioRxiv · Jan 3, 2020Biochemistry