A. Beck

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma

This study shows that BRAF/MEK inhibition induces cell state transitions in BRAFV600E-mutant gliomas, leading to PD-L1 upregulation and immune evasion, which can be overcome by combining with immune checkpoint inhibition.

Non-Synonymous, Synonymous, and Non-Coding Nucleotide Variants Contribute to Recurrently Altered Biological Processes During Retinoblastoma Progression

The paper identifies contributions of non-synonymous, synonymous, and non-coding variants to recurrent biological processes in retinoblastoma progression using genomic and functional analyses.

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

This study shows SARS-CoV-2 evades NK cell killing by downregulating NKG2D ligands via Nsp1, reducing NK cell cytotoxicity against infected cells.

High diversity of type I polyketide genes in Bacidia rubella as revealed by the comparative analysis of 23 lichen fungal genomes

The paper analyzes 23 lichen fungal genomes to reveal high diversity of Type I polyketide synthase genes and their biosynthetic potential.

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

This paper introduces a suspension culture technique for cancer organoids that improves expansion efficiency and enables large-scale perturbation screens.

Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer

This study shows that delivering a childhood vaccine antigen via attenuated Listeria improves immunotherapy for pancreatic cancer by converting cold tumors into hot tumors and enhancing T cell activity.

Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice

This study shows that combining nicotinamide with gemcitabine reduces pancreatic tumor growth and improves survival in mice by modulating the immune microenvironment.

Middle-level IM-MS and CIU experiments for improved therapeutic immunoglobulin isotype fingerprinting

This paper introduces middle-level IM-MS and CIU methods for improved mAb isotyping, showing better differentiation of IgG isotypes compared to intact-level analysis.

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.