Deletion of Sod1 in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice
N. Pollock, P. C. Macpherson, C. A. Staunton, K. Hemmings, C. S. Davis, E. D. Owen, A. Vasilaki, H. Van Remmen, A. Richardson, A. McArdle, S. V. Brooks, M. J. Jackson
This study shows that deleting Sod1 in motor neurons worsens age-related muscle atrophy and NMJ changes in old mice, but not in younger mice.
bioRxiv · Jan 27, 2022 · PreprintPhysiology