The Mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs
S. Cioccolo, J. Barritt, N. Pollock, Z. Hall, J. Babuta, P. Sridhar, A. Just, N. Morgner, T. R. Dafforn, I. Gould, B. Byrne
This paper shows MmpL3 from M. smegmatis forms dimers in various membrane mimetic systems, contradicting previous structural studies suggesting monomerism.
bioRxiv · May 6, 2024Biophysics