Anticancer drug doxorubicin spontaneously reacts with GTP and dGTP
G. Mejia, L. Su, P. Pandey, K. J. Dit Fouque, A. McGoron, F. Fernandez-Lima, J. He, A. Mebel, F. Leng
This study shows doxorubicin forms covalent conjugates with GTP and dGTP, which are less cytotoxic and cannot enter nuclei, suggesting doxorubicin may target nucleotides involved in cellular energy processes.
bioRxiv · Oct 7, 2022Cancer Biology