Author

F. Fernandez-Lima

Primary ORCID profile (0000-0002-1283-4390 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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F. Fernandez-LimaiD1 paper

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

F. Leng· 2 shared L. Su· 2 shared A. Fusco· 1 shared A. Garabedian· 1 shared A. McGoron· 1 shared A. Mebel· 1 shared F. DAlessio· 1 shared F. Falanga· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

F. Leng

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2 papers

Recent·Most cited

Anticancer drug doxorubicin spontaneously reacts with GTP and dGTP

G. Mejia, L. Su, P. Pandey, K. J. Dit Fouque, A. McGoron, F. Fernandez-Lima, J. He, A. Mebel, F. Leng

This study shows doxorubicin forms covalent conjugates with GTP and dGTP, which are less cytotoxic and cannot enter nuclei, suggesting doxorubicin may target nucleotides involved in cellular energy processes.

bioRxiv · Oct 7, 2022Cancer Biology

Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA

L. Su, N. Bryan, S. Battista, J. Freitas, A. Garabedian, F. DAlessio, M. Romano, F. Falanga, A. Fusco, L. Kos, J. Chambers, F. Fernandez-Lima, P. P. Chapagain, S. Vasile, L. Smith, F. Leng

This study identifies suramin as a potent inhibitor of HMGA2-DNA binding, showing it disrupts HMGA2 function and induces differentiation of brain tumor stem cells.

bioRxiv · Nov 12, 2019 · PreprintBiochemistry