Cancer BiologybioRxiv
Anticancer drug doxorubicin spontaneously reacts with GTP and dGTP
G. Mejia, L. Su, P. Pandey…·F. Leng
This study shows doxorubicin forms covalent conjugates with GTP and dGTP, which are less cytotoxic and cannot enter nuclei, suggesting doxorubicin may target nucleotides involved in cellular energy processes.
DOI 10.1021/acs.chemrestox.2c00367