L. Su

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

Identification, structure and function of the methyltransferase involved in the biosynthesis of the dithiolopyrrolone antibiotic xenorhabdin

This study identifies and characterizes XrdM, an amide methyltransferase involved in dithiolopyrrolone antibiotic biosynthesis, and shows it is distinct from DtpM in structure and function.

Metabolites with benzene ring from sugarcane leaf play important role in plant-Spodoptera frugiperda interaction

The paper identifies benzene-ring containing metabolites in sugarcane that influence Spodoptera frugiperda behavior and development, with some promoting insect growth and others repelling them.

Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways

This study discovers three novel siderophore series from Streptomyces ambofaciens, showing biosynthesis via crosstalk between two NRPS-independent pathways.

Exploring Urban Street Green Perception from the Perspective of Combining GVI and NDVI: A Case Study of Zhongshan City, Guangdong Province

This study combines GVI and NDVI to analyze urban street greening in Zhongshan City, finding strong correlation and scale sensitivity, and proposes optimization strategies.

Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human liver and immune system

This study shows that dually humanized mice can support persistent HBV and HIV coinfections, enabling research on immune dysregulation and immunotherapeutic testing.

CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

The paper shows that anti-CTLA-4 ADC treatment causes B cell depletion via T cell hyper-proliferation and regulatory T cell impairment in CTLA-4 knock-in mice.

BCAT1 inhibition affects CD8+ T cell activation, exhaustion, and tumoral immunity by altering iron homeostasis

This study shows BCAT1 inhibition alters iron homeostasis, affecting CD8+ T cell activation, exhaustion, and tumor immunity, with potential as a cancer therapy.

Anticancer drug doxorubicin spontaneously reacts with GTP and dGTP

This study shows doxorubicin forms covalent conjugates with GTP and dGTP, which are less cytotoxic and cannot enter nuclei, suggesting doxorubicin may target nucleotides involved in cellular energy processes.

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism

This study shows that CD45-linked NKR antagonists enhance NK and T cell activity more than traditional antibodies, revealing potential for improved cancer immunotherapies.

CAR-T Engager Proteins Optimize Anti-CD19 CAR-T Cell Therapies for Lymphoma

This paper introduces a CAR-T Engager protein that prevents and reverses lymphoma relapse by maintaining CD19 antigen presence on cancer cells.

Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

The Influence of Leaf Anatomical Traits on Photosynthetic in Coffee Leaves

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.

SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens

Large-scale miRNA-Target Data Analysis to Discover miRNA Co-regulation Network of Abiotic Stress Tolerance in Soybeans

The paper uses computational methods to predict miRNA-target regulatory modules in soybeans under abiotic stress and identifies stress-related modules with gene ontology enrichment.

Small RNA profiling in Mycobacterium insights into stress adapt ability

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

Multi-omics consensus ensemble refines the classification of muscle-invasive bladder cancer with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

DNMT family induced down-regulation of NDRG1 via DNA methylation and clinicopathological significance in gastric cancer

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

A functional chromogen gene C from wild rice is involved in a different anthocyanin biosynthesis pathway in indica and japonica

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

The genetic architecture underlying ecological adaptation in Atlantic herring is not consistent with the infinitesimal model

The study identifies hundreds of loci associated with ecological adaptation in Atlantic herring, finding that allele frequency shifts at these loci contradict the infinitesimal model for complex traits.

A hybrid cyt c maturation system enhances the bioelectrical performance of engineered Escherichia coli by improving the rate-limiting step

This paper improves the bioelectrical performance of engineered E. coli by enhancing the cytochrome c maturation system with hybrid domains from E. coli and Shewanella oneidensis MR-1, increasing current output and electron flux.

CD19-targeting CAR T cells potently redirected to kill solid tumor cells

This paper develops CD19-targeting CAR T cells that secrete bridging proteins to enhance tumor targeting and cytotoxicity in solid tumors.

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA

This study identifies suramin as a potent inhibitor of HMGA2-DNA binding, showing it disrupts HMGA2 function and induces differentiation of brain tumor stem cells.

HIV-1 Vpr Degrades TET2 to Suppress IRF7 and Interferon Expression in Plasmacytoid Dendritic Cells

This study shows HIV-1 Vpr suppresses IRF7 and IFN-I expression in pDCs by degrading TET2, thereby enhancing HIV-1 replication.

Interleukin 11 expression causes murine inflammatory bowel disease

This study shows that IL11 secretion from stromal cells drives inflammatory bowel disease in mice, suggesting IL11 as a therapeutic target for inflammatory bowel disease.

Development of SGC-GAK-1 as an orally active in vivo probe for cyclin G associated kinase through cytochrome P450 inhibition

The paper develops SGC-GAK-1 as an orally active in vivo probe for GAK by using cytochrome P450 inhibition to improve its metabolic stability and plasma exposure.