Acquired resistance to PD-L1 inhibition is associated with an enhanced type I IFN-stimulated secretory program in tumor cells
Y. Shi, M. Dolan, M. Mastri, A. McKenery, J. W. Hill, A. Dommer, S. Benzekry, M. Long, S. Abrams, I. Puzanov, J. M. L. Ebos
This study identifies an IFN-stimulated secretory program in PD-L1-resistant tumors that promotes immune evasion and shows that targeting this program can inhibit tumor growth.
bioRxiv · Jul 1, 2021 · PreprintCancer Biology