Author

S. Abrams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2

Frequent Co-Authors

C.-H. Toh· 2 shared G. Wang· 2 shared A. Cicala· 1 shared A. Craig· 1 shared A. Dommer· 1 shared A. McKenery· 1 shared A. Officer· 1 shared A. Pagenkopf· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersPathology

C.-H. Toh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Bayesian approach to estimate the probability of resistance to bedaquiline in the presence of a genomic variant

D. Z. Anlay, E. Riviere, P. H. T. Tu, S. Abrams, A. Van Rie

The paper uses Bayesian methods to estimate bedaquiline resistance probabilities based on genomic variants and expert opinions, finding varying probabilities across mutation types.

bioRxiv · Aug 30, 2022Microbiology

Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

A. Papadas, G. Deb, A. Officer, A. Cicala, C. Hope, P. Emmerich, J. Wiesner, A. Pagenkopf, G. Arauz, V. Bansal, K. Matkowskyj, D. A. Deming, K. Politi, S. Abrams, O. Harismendy, F. Asimakopoulos

The paper shows that stromal remodeling generates signals that regulate dendritic cell survival and activity, enhancing T-cell inflammation in the tumor microenvironment.

bioRxiv · Nov 10, 2021Immunology

Acquired resistance to PD-L1 inhibition is associated with an enhanced type I IFN-stimulated secretory program in tumor cells

Y. Shi, M. Dolan, M. Mastri, A. McKenery, J. W. Hill, A. Dommer, S. Benzekry, M. Long, S. Abrams, I. Puzanov, J. M. L. Ebos

This study identifies an IFN-stimulated secretory program in PD-L1-resistant tumors that promotes immune evasion and shows that targeting this program can inhibit tumor growth.

bioRxiv · Jul 1, 2021 · PreprintCancer Biology

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway

Z. wang, z. Cheng, S. Abrams, z. Lin, E. yates, q. Yu, w. Yu, P. Chen, C.-H. Toh, G. Wang

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

bioRxiv · Sep 17, 2020Pathology

Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

E. Knudsen, V. Kumarasamy, S. Chung, P. Vail, S. Tzetzo, A. Ruiz, M. Seshadri, S. Abrams, J. Wang, A. Witkiewicz

This study shows that combining MEK and CDK4/6 inhibitors with immune checkpoint inhibitors improves pancreatic cancer treatment by enhancing T-cell infiltration and altering myeloid populations in preclinical models.

bioRxiv · Dec 5, 2019Cancer Biology

Parasite histones mediate leak and coagulopathy in cerebral malaria

C. A. Moxon, Y. Alhamdi, J. Storm, J. Toh, J. Y. Ko, G. Murphy, T. Taylor, K. Seydel, S. Kampondeni, M. Potchen, J. O'Donnell, N. O'Regan, G. Wang, G. Garcia-Cardena, M. Molyneux, , C.-H. Toh

This study shows parasite histones contribute to coagulopathy and vascular leak in cerebral malaria, leading to brain swelling and poor outcomes.

bioRxiv · Mar 20, 2019 · PreprintMicrobiology