H2A.Z chaperones converge on histone H4 acetylation for melanoma cell proliferation
S. Jostes, C. Vardabasso, J. Dong, S. Carcamo, R. Singh, R. Phelps, A. Meadows, D. Hasson, E. Bernstein
This study shows that H2A.Z chaperones SRCAP, P400, and YL1 regulate H4 acetylation and cell cycle genes in melanoma, with YL1 loss inducing apoptosis and correlating with poor patient outcomes.
bioRxiv · Nov 26, 2023 · PreprintCancer Biology