J. Dong

The C terminus of infectious bursal disease virus (IBDV) VP3 encodes a predicted intrinsically disordered region (IDR), which promotes the formation of cytoplasmic puncta and modulates their physical properties.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Terrestrial ecosystems enhance root zones in response to intensified drought

The paper quantifies a 11% global increase in root zone water storage capacity from 1982-2020, highlighting its impact on hydrological and ecological processes under climate change.

H2A.Z chaperones converge on histone H4 acetylation for melanoma cell proliferation

This study shows that H2A.Z chaperones SRCAP, P400, and YL1 regulate H4 acetylation and cell cycle genes in melanoma, with YL1 loss inducing apoptosis and correlating with poor patient outcomes.

Mass spectrometry imaging links interxylary cork formation with phytochemical distribution in Scutellaria baicalensis

This study uses mass spectrometry imaging to show that interxylary cork formation in Scutellaria baicalensis correlates with spatial phytochemical distribution, revealing distinct flavonoid accumulation patterns in different root tissue decay stages.

Spatiotemporal development of growth and death zones in expanding bacterial colonies driven by emergent nutrient dynamics

This study shows that bacterial colony expansion is driven by mechanical constraints and nutrient gradients, with cell death occurring in a distinct zone due to glucose depletion and anaerobiosis.

Von Willebrand Factor Synergizes with Tumor-Derived Extracellular Vesicles to Promote Gastric Cancer Metastasis

This study shows that von Willebrand factor (VWF) and gastric cancer-derived extracellular vesicles (gcEVs) work together to promote metastasis by disrupting endothelial integrity and facilitating cancer cell migration.

BacScan: An Unbiased and Genome-Wide Approach to Identify Bacterial Highly Immunogenic Proteins

BacScan identifies highly conserved immunogenic bacterial proteins across serotypes, showing potential for vaccine development.

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

This study evaluates γδ T cell-mediated cytotoxicity against cervical organoids, finding that HPV-transformed and cancerous organoids are more susceptible than healthy ones.

PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

Cryo-EM structure of TMEM63C suggests it functions as a monomer

The paper determines the cryo-EM structure of mouse TMEM63C, reveals structural differences from plant orthologues, and shows TMEM63C functions as a monomer while TMEM63B is a mix of monomer and dimer.

Click-Based Determination of Accumulation of Molecules in Escherichia coli

The paper develops CHAMP, a method to measure cytosolic accumulation of azide-tagged molecules in Gram-negative bacteria, enabling high-throughput screening of over 1,000 compounds.

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Proliferating cell nuclear antigen involves in temperature stress tolerance of Ulva prolifera

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

Risk assessment during nest defense against three simulated predators by female northern house wrens (Troglodytes aedon)

This study examines how female northern house wrens adjust their nest defense behaviors based on perceived predator risk, finding that they respond differently to predators that threaten their offspring versus those that threaten both offspring and themselves.

Potently neutralizing human monoclonal antibodies against the zoonotic pararubulavirus Sosuga virus

The paper identifies potent human monoclonal antibodies against Sosuga virus, revealing epitope diversity and neutralization mechanisms.

Permeation Across the Mycomembrane in Live Mycobacteria

The paper develops a novel assay to measure small molecule permeation across the mycomembrane of mycobacteria, revealing variability in permeability profiles between species.

Targeted Protein Degradation via Nanoparticles

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

Integrative analysis of the MD Anderson Prostate Cancer Patient-Derived Xenograft Series (MDA PCa PDX)

The paper characterizes the genomic and transcriptomic landscape of MDA PCa PDX models and develops an organoid platform to study prostate cancer heterogeneity and resistance.

The brassinosteroid biosynthesis gene TaD11-2A controls grain size and its elite haplotype improves wheat grain yields

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

An enzyme-based system for the extraction of small extracellular vesicles from plants

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

Changes of small non-coding RNAs by severe acute respiratory syndrome coronavirus 2 infection

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

Respiratory Syncytial virus NS1 protein targets the transactivator binding domain of MED25

This paper identifies the interaction between RSV NS1 and MED25's ACID domain, showing NS1 competes with ATF6 to inhibit innate immune gene transcription.

Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway

This study shows propionate improves diabetes-induced neurological dysfunction by enhancing cerebral microcirculation, reducing oxidative stress, and activating the PI3K/Akt/eNOS signaling pathway in diabetic mice.

Antigen identification and high-throughput interaction mapping by reprogramming viral entry

This paper introduces RAPTR, a method to identify antigens and map their interactions with immune receptors using viral pseudotyping and single-cell sequencing.

Gastric cancer derived exosomes induce peritoneal mesothelial cell EMT through TGF-β1/Smads pathway to promote peritoneal metastasis

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

Dynamic metabolic exchanges between complementary bacterial types provide collaborative stress resistance

The paper studies metabolic interactions between bacterial species under acidification, showing how complementary metabolic strategies enable collaborative stress resistance and dynamic ecosystem behavior.

Precision Genome and Base Editing by Regulating mRNA Nuclear Export Using Selective Inhibitors of Nuclear Export

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicine

The paper challenges the role of IL6 in liver regeneration, showing HyperIL6 protects against liver damage and promotes regeneration independently of STAT3, highlighting IL11 as a new therapeutic target.