R. Singh

Machine learning on multiple epigenetic features reveals H3K27Ac as a driver of gene expression prediction across patients with glioblastoma.

Genetic and cellular basis of impaired phagocytosis and photoreceptor degeneration in CLN3 disease.

This study investigates how CLN3 mutations impair phagocytosis and cause photoreceptor degeneration in CLN3 disease using patient-derived cells and a miniswine model.

MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids

This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

The 3'-untranslated regions of yeast ribosomal protein mRNAs determine paralog incorporation into ribosomes and recruit factors necessary for specialized functions

Sbh1/Sec61beta is a specific signal peptide receptor within the Sec61 channel

This study identifies Sbh1/Sec61β as a specific signal peptide receptor that recognizes and guides substrates into the Sec61 channel through its cytosolic IDR and conserved regions.

Tar Spot Disease Severity Influences Phyllosphere-Associated Bacterial and Fungal Microbiomes

The paper investigates how tar spot disease severity in corn affects phyllosphere bacterial and fungal microbiomes, finding distinct communities in resistant versus susceptible lines.

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells

This study shows that TIMP3 mutations in RPE cells increase glycolytic activity and disrupt glutamine metabolism, linking these changes to Sorsbys Fundus Dystrophy.

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

Optimizing Glycemic Control in Type 1 Diabetic Patients using a Deep Learning-Based Artificial Pancreas with a Secure Glucagon and Insulin Delivery System

Modeling aging and retinal degeneration with mitochondrial DNA mutation burden.

This study uses a POLG deficiency model to show that mtDNA mutations cause retinal degeneration through impaired mitochondrial function and accelerated aging.

H2A.Z chaperones converge on histone H4 acetylation for melanoma cell proliferation

This study shows that H2A.Z chaperones SRCAP, P400, and YL1 regulate H4 acetylation and cell cycle genes in melanoma, with YL1 loss inducing apoptosis and correlating with poor patient outcomes.

Septins Enable T Cell Contact Guidance via Amoeboid-Mesenchymal Switch

This study shows that septins regulate T cell migration modes by switching between amoeboid and mesenchymal movement, with mesenchymal migration relying on microtubules and dynein motors.

Differential early-life survival underlies the adaptive significance of temperature-dependent sex determination in a long-lived reptile

The study tests the survival-to-maturity hypothesis for temperature-dependent sex determination in alligators, finding male-promoting temperatures enhance hatchling survival regardless of sex.

DNA Tetrahedral Nanocages as a Promising Nanocarrier for Dopamine Delivery in Neurological Disorders

This study investigates DNA tetrahedral nanocages as a dopamine carrier for treating neurological disorders, showing their ability to deliver dopamine to cells and zebrafish embryos.

Revealing Chloroquine's Antimalarial Mechanism: The Suppression of Nucleation Events during Heme to Hemozoin Transformation

This study shows chloroquine delays hemozoin production by perturbing nucleation events rather than inhibiting crystal growth or substrate availability.

Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing

This study investigates how ATP hydrolysis by MDA5 and LGP2 influences viral RNA sensing, showing MDA5's selectivity and LGP2's role in modulating MDA5 filament assembly.

Interruption of the Intratumor CD8:Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy

This study shows that interrupting CD8:Treg crosstalk during PD-1 immunotherapy improves melanoma control by reducing Treg accumulation.

Metabolic alterations unravel the materno fetal immune responses with disease severity in pregnant women infected with SARS-CoV-2

This study examines metabolic and immune changes in pregnant women with SARS-CoV-2 infection, finding altered metabolic pathways and cytokine profiles associated with disease severity.

Lipid modification of DNA nanocages enhances cellular uptake, migration, and in vivo uptake

This study modifies DNA nanocages with a cationic lipid to improve their cellular uptake, migration, and in vivo uptake in zebrafish embryos.

CREID- A ChemoReceptor-Effector Interaction Database

CREID provides a database of bacterial chemoreceptor-effector interactions, offering insights into bacterial sensing mechanisms and applications for biosensor development.

Methotrimeprazine exerts antiviral and neuroprotective effects in Japanese encephalitis virus infection through activation of adaptive ER stress and autophagy

This study identifies Methotrimeprazine as a drug that reduces JEV infection through autophagy and ER stress, with neuroprotective and antiviral effects in a mouse model.

Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer

This study identifies dynein-powered locomotion as a complementary mechanism to actomyosin-driven movement in metastatic breast cancer cells, showing its necessity and sufficiency in 3D migration.

A multiplex PCR assay for the detection of Cryptosporidium species and simultaneous differentiation of Cryptosporidium hominis, Cryptosporidium parvum in clinical stool samples

This paper develops a multiplex PCR assay to detect and differentiate Cryptosporidium species in stool samples without post-amplification sequencing, achieving high specificity and cost-effectiveness.

Enhanced protective efficacy of a novel, thermostable, RBD-S2 fusion immunogen against SARS-CoV-2 and its variants

This study evaluates a novel RBD-S2 fusion immunogen that shows enhanced protection against SARS-CoV-2 and its variants in animal models.

Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity and neutralization sensitivity

This study investigates how mutations in the S2 subunit of SARS-CoV-2 Omicron spike affect its structure, fusogenicity, and neutralization sensitivity.

Biophysical Characterization and Interaction study of WhiB6 Protein of Mycobacterium tuberculosis with Nucleic Acid

This study characterizes the biophysical interaction between WhiB6 protein and espA promoter DNA using multiple spectroscopic methods, revealing structural changes and potential therapeutic targets.

Wolbachia-infected pharaoh ant colonies have higher egg production, metabolic rate, and worker survival