V. Simon

Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines

This study evaluates monoclonal antibody responses to XBB.1.5 vaccines by analyzing plasmablasts from vaccinated individuals and characterizing their binding and neutralization properties against SARS-CoV-2 variants.

SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestrate Pseudomonas copper resistance

This paper investigates how copper resistance in Pseudomonas is regulated by cross-talk between conserved and accessory two-component systems, revealing their integration into regulatory networks.

A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

This study shows that GLP-1 receptor activation in the olfactory bulb enhances insulin secretion via a sympathetic pathway involving the paraventricular nucleus.

Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection

This study compares mucosal antibody responses in individuals who received mRNA booster vaccinations or experienced breakthrough infections, finding that breakthrough infections induce stronger saliva sIgA responses than boosters.

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

Antigenic landscape analysis of individuals vaccinated with a universal influenza virus vaccine candidate reveals induction of cross-subtype immunity

The paper analyzes immune responses to a universal influenza vaccine using a microarray to show broad antibody coverage against group 1 hemagglutinins.

Mapping SARS-CoV-2 antigenic relationships and serological responses

The paper uses antigenic cartography to analyze cross-reactivity among SARS-CoV-2 variants and human sera, identifying amino acid substitutions and immunodominance patterns affecting immune escape and vaccine efficacy.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

This study evaluates the antiviral activity of nirmatrelvir, molnupiravir, and remdesivir against the SARS-CoV-2 Omicron variant and confirms their potency.

Development of an HIV reporter virus that identifies latently infected CD4+ T cells

This study develops an HIV reporter virus to identify latently infected CD4+ T cells and finds that over 50% of infected cells harbor silent proviruses.

The T cell receptor repertoire reflects the dynamics of the immune response to vaccination

This study uses TCR repertoire sequencing to analyze immune responses to vaccines, finding broader T cell responses to COVID-19 than Influenza and TCR as a fingerprint for individual identification.

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

Structure of a germline-like human antibody defines a neutralizing epitope on the SARS-CoV-2 spike NTD

The paper structures a germline-like antibody in complex with SARS-CoV-2 spike NTD, revealing a neutralizing epitope and its conservation across variants.

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

This study identifies the ULBR in Src as essential for its oncogenic activity by modulating membrane substrate phosphorylation.

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase

This study identifies novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase and characterizes escape mutations and their impact on viral fitness.

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

The paper functionally and antigenically characterizes the hemagglutinin and neuraminidase of Wuhan spiny eel influenza virus to assess its status as a bona fide influenza virus.

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

Transcription inhibitors with XRE DNA-binding and cupin signal-sensing domains drive metabolic diversification in Pseudomonas

The paper identifies XRE-cupin transcription factors in Pseudomonas aeruginosa that inhibit neighboring genes involved in metabolic pathways, revealing their role in metabolic diversification.

Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice

This study shows that HIV variants with suboptimal anti-APOBEC3G activity are attenuated without treatment but gain a fitness advantage under antiretroviral therapy in humanized mice.

Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation

This study identifies a dimerization mechanism in the pseudo-kinase Pragmin that regulates protein tyrosine phosphorylation through interaction with CSK.