Cancer BiologybioRxiv
Non-canonical glutamate-cysteine ligase activity protects against ferroptosis
Y. P. Kang, A. Mockabee-Macias, C. Jiang…·G. M. DeNicola
This study identifies a non-canonical role of glutamate-cysteine ligase in preventing glutamate accumulation and ferroptosis under cystine starvation.
DOI 10.1016/j.cmet.2020.12.007