Cell BiologybioRxivPreprint
Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes
J. Kaserman, R. B. Werder, F. Wang…·A. A. Wilson
This study uses CRISPR-Cas9 to create syngeneic iPSC-derived hepatocytes with ZAAT heterozygosity, revealing metabolic dysregulation and cellular heterogeneity in MZ and ZZ cells.