Differential modularity of the mammalian Engrailed 1 enhancer network directs eccrine sweat gland development
D. Aldea, B. Kokalari, Y. Atsuta, H. L. Dingwall, Y. Zheng, A. Nace, G. Cotsarelis, Y. G. Kamberov
The paper identifies a conserved enhancer, ECE20, that regulates Engrailed 1 expression in both mouse and human skin and brain, while showing that ECE18 is lineage-specific and not required in mice.
bioRxiv · Sep 14, 2022Evolutionary Biology