Y. Zheng

The paper analyzes metagenomes from cold seeps to create a database showing microbial diversity and potential natural products.

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

This paper develops a framework to generate virtual retinal vasculatures and models their haemodynamics to study the relationship between vascular structure and retinal perfusion.

The paper uses SNP data from Huidobria fruticosa to show recent population structure shaped by climate change over the last 2 million years in the Atacama Desert.

This study shows that temperature-sensitive condensation of SUF4 protein regulates FLC transcription and flowering time in Arabidopsis.

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

This study shows Prdm1 regulates liver cNK cells and ILC1s, affecting cancer metastasis and immune communication, with implications for liver cancer immunotherapy.

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

This paper introduces GRAPE-Net, a graph-based model that stratifies bronchial premalignant lesions using histopathology images, showing improved classification accuracy for lung cancer subtypes.

The paper shows that DHRS7 loss increases nuclear size in prostate cancer cells and that estradiol propionate reduces nuclear size in DHRS7-lacking cells, suggesting DHRS7 as a biomarker for estrogen therapy effectiveness.

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

The paper identifies haplotypic independence as a mechanism enabling long-term survival of an asexual mite species without sex.

The paper investigates whether gene copy number distribution changes in European and Asian populations during the human out-of-Africa expansion are due to demographic factors or adaptive selection.

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

This study reveals a reverse-central-dogma pathway by which ribosome antibiotics cause genomic instability and accelerate resistance evolution through transcription-translation coupling disruption.

The paper introduces a flexible, cost-effective behavioral platform for spatial cognition research with software tools for precise neural event timing and reward delivery.

This study identifies FOXM1 as an epigenetic regulator in EAC that suppresses anti-tumor immune responses by inhibiting CD8+ T cell infiltration and function.

The paper uses patient-derived organoids to model metastatic neuroendocrine carcinoma of the cervix and guide personalized treatment based on drug screening.

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

This study identifies Nin domains critical for its localization, interactions with dynein and ensconsin, and microtubule organization in Drosophila.

This study uses single-cell spatial analysis to identify immune and metabolic tumor microenvironment signatures associated with response and resistance to immunotherapy in head and neck cancer.

The paper identifies BuGZ as a tubulin GEF that binds GDP-tubulin and promotes GTP exchange, challenging the belief that such a factor is unnecessary.

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

This study improves a DNA polymerase's ability to incorporate modified nucleotides through combinatorial mutagenesis, resulting in a 20-fold efficiency gain.

This study identifies (1S)-exo-3-hydroxycamphor as a volatile sex attractant pheromone produced by female winter fireflies, Photinus corrusca, and demonstrates its sensory detection in males.

This study shows that exosomal CXCL1 from dying breast cancer cells promotes metastasis by activating TAM/PD-L1 signaling and identifies TPCA-1 as a potential inhibitor.

The paper shows Foxp3 is essential for establishing Treg-specific 3D chromatin architecture during differentiation, though not dependent on a specific dimer formation.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.