Scalable Production and Purification of Engineered ARRDC1-Mediated Microvesicles in a HEK293 Suspension Cell System
K. Luther, A. Navaei, L. Gens, C. Semple, P. Moharil, I. Passalacqua, K. Vyas, Q. Wang, S.-L. Liu, L. Sun, S. Ramaswamy, D. Zocco, J. Nabhan
This study develops scalable methods to produce and purify engineered ARRDC1-mediated microvesicles (ARMMs) for gene therapy delivery, showing efficient production and in vivo biodistribution.
bioRxiv · May 14, 2024Bioengineering