L. Sun

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

This study develops scalable methods to produce and purify engineered ARRDC1-mediated microvesicles (ARMMs) for gene therapy delivery, showing efficient production and in vivo biodistribution.

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

This study identifies RIPK3-dependent necroptosis as the main cause of immunodeficiency in RIPK1-deficient rats and suggests necroptosis inhibition as a potential therapy.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

MagPEG provides a high-throughput EV isolation method with integrated molecular profiling, achieving faster and more efficient results than existing techniques.

This study identifies Naproxen as a chemical inhibitor of PIN auxin transporters in plants, revealing its mechanism of action through cellular, biochemical, and structural analyses.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

This study investigates the anti-hepatoblastoma effects of the compound AE-848, showing it inhibits cell proliferation, induces apoptosis, and reduces tumor growth in vivo.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This paper demonstrates that engineered microbial biofilms can generate electricity from water evaporation, achieving power densities higher than non-biological materials.

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study characterizes a Mycobacterium tuberculosis dipeptidyl peptidase with high thermal stability and shows its potential role in immune modulation.

This study identifies L13Rik as a lncRNA that promotes mesangial cell injury in diabetic nephropathy by regulating the miR-2861/CDKN1B axis.

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

This study identifies Zfp335 as a transcription factor regulating T cell development by controlling TCRβ expression and cell survival through β-selection-dependent and -independent mechanisms.

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.