A. Navon

Alternative splicing of SLAMF6 in human T cells creates a co-stimulatory isoform that counteracts the inhibitory effect of the full-length receptor

This study identifies an alternative splicing event in SLAMF6 that generates a co-stimulatory isoform, which enhances T cell cytotoxicity and is associated with improved anti-tumor responses in melanoma.

{-}{-}{-}{-}{-}Polyglutamine-related aggregates serve as a potent antigen source for cross presentation by dendritic cells

The paper shows that polyglutamine-related aggregates from apoptotic cells are efficiently processed by dendritic cells for cross-presentation, ensuring antigenic overlap necessary for T cell immunity.