G. Eisenberg

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

This study identifies an alternative splicing event in SLAMF6 that generates a co-stimulatory isoform, which enhances T cell cytotoxicity and is associated with improved anti-tumor responses in melanoma.

This study shows that SLAMF6 deficiency enhances T cell tumor-killing ability and shifts T cells toward an effector phenotype, suggesting SLAMF6 as a new immune checkpoint.