D. Weichenhan

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.

Multidimensional Characterization of Soft-Tissue Sarcomas with FUS-TFCP2 or EWSR1-TFCP2 Fusions

This study characterizes soft-tissue sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions through multi-omics analyses and functional studies, identifying therapeutic targets and mechanisms of disease.

Aberrant MNX1 Expression Associated with t(7;12)(q36;p13) Pediatric Acute Myeloid 1 Leukemia Induces the Disease Through Altering Histone Methylation

This study identifies MNX1 as a driver of t(7;12)(q36;p13) pediatric AML by altering histone methylation and shows that targeting MNX1 can prevent leukemia development.

High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts

This study identifies novel epigenetic and transcriptomic regulators of COPD in human lung fibroblasts across disease stages.

MEOX2 homeobox gene promotes growth of malignant gliomas

This study identifies MEOX2 as an oncogenic transcription factor in glioblastoma, showing it promotes tumor growth through ERK signaling and cooperates with p53 and PTEN loss.

Diverse routes of Club cell evolution in lung adenocarcinoma

This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.

Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

This study investigates AID's role in DNA methylation defects in HIGM2 B cells, finding that AID is not directly involved in active demethylation but TET enzymes are, and that methylation defects are linked to premature BCR activation.