Cell-intrinsic ceramides determine T cell function during melanoma progression
M. Hose, A. Günther, E. Naser, F. Schumacher, T. Schönberger, J. Falkenstein, A. Papadamakis, B. Kleuser, K. A. Becker, E. Gulbins, A. Haimovitz-Friedman, J. Buer, A. Westendorf, W. Hansen
This study shows that ceramide levels in T cells affect their function during melanoma progression, with reduced ceramide impairing T cell responses and elevated ceramide enhancing cytotoxic activity.
bioRxiv · Aug 31, 2022Immunology