Author

B. Kleuser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. Schumacher· 4 shared A. Günther· 2 shared A. Westendorf· 2 shared E. Gulbins· 2 shared J. Buer· 2 shared M. Hose· 2 shared W. Hansen· 2 shared A. Chaban· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMicrobiology

F. Schumacher

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of Chlamydia trachomatis

M. R. Babu Sait, L. H. Jachmann, M. Milivojevic, C. Llorente-Saez, S. Dhanjal, F. Schumacher, S. Henriksson, N. V. Gayathri Vegesna, A. Chaban, P. Mohanty, M. Ölander, S. Muraleedharan, S. Farmand Azadeh, B. Kleuser, B. Schmierer, B. S. Sixt

The paper identifies CpoS as a key effector for maintaining Chlamydia trachomatis vacuole integrity by regulating sphingolipid supply and shows that disrupting this pathway can clear infection without harming host cells.

PLOS Biology · Aug 12, 2025Peer-reviewedMicrobiology

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

E. Wortmann, A. Osswald, D. Wylensek, S. Kuhls, O. Coleman, Q. Ducarmon, W. Liang, N. Treichel, F. Schumacher, C. Volet, S. Matysik, K. Kleigrewe, M. Gigl, S. Rohn, B. Kleuser, , T. Clavel

The paper shows that secondary bile acids from gut bacteria worsen colorectal cancer in a Western diet model.

bioRxiv · Mar 17, 2023 · PreprintMicrobiology

Cell-intrinsic ceramides determine T cell function during melanoma progression

M. Hose, A. Günther, E. Naser, F. Schumacher, T. Schönberger, J. Falkenstein, A. Papadamakis, B. Kleuser, K. A. Becker, E. Gulbins, A. Haimovitz-Friedman, J. Buer, A. Westendorf, W. Hansen

This study shows that ceramide levels in T cells affect their function during melanoma progression, with reduced ceramide impairing T cell responses and elevated ceramide enhancing cytotoxic activity.

bioRxiv · Aug 31, 2022Immunology

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

A. Günther, M. Hose, F. Schumacher, B. Kleuser, K. Matuschewski, K. S. Lang, E. Gulbins, J. Buer, A. Westendorf, W. Hansen

This study shows that acid ceramidase deficiency reduces parasitemia in Plasmodium yoelii-infected mice by impairing erythropoiesis and T cell responses.

bioRxiv · Mar 8, 2022Microbiology