LRRK2 Phosphorylates Neuronal Elav RNA-Binding Proteins to RegulatePhenotypes Relevant to Parkinson's Disease
A. Pastic, O. Negeri, A. Ravel-Chapuis, A. Savard, M. T. Trung, G. Palidwor, H. Guo, P. Marcogliese, J. A. Taylor, H. Okano, L. Trinkle-Mulcahy, B. J. Jasmin, D. Park, D. Gibbings
This study shows LRRK2 phosphorylates neuronal ELAV proteins, affecting mRNA regulation and contributing to Parkinson's disease pathology in mice.
bioRxiv · Apr 24, 2022 · PreprintCell Biology